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diagnosis hematology management oncology symptoms leukemia causes chronic cll complications differential differentiation erythematosus gastrointestinal hemophagocytic hlh hypertension injury leukostasis lupus
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... ATRA treatment Pathophysiology ... : • Common: fever ... #APML #diagnosis
Acute Spinal Cord Injuries: Pathogenesis and clinical findings • Anterior Cord Syndrome -> Anterior spinal artery
Acute Spinal Cord ... Anterior Cord Syndrome ... weakness and #Acute ... #diagnosis #pathophysiology ... #signs #symptoms
Systemic Lupus Erythematosus: Gastrointestinal Manifestations - Thrombosis of vessels in the pancreas, Vasculitis -> Acute Pancreatitis
Vasculitis -> Acute ... Pancreatitis - Elevated Liver ... - Budd Chiari Syndrome ... Complications #pathophysiology ... #signs #symptoms
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... Headaches, bone pain, fever ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
significant portal HTN Signs ... and hepatorenal syndrome ... • Budd Chiari syndrome ... • Cirrhosis/acute ... Diagnosis #causes #hepatology
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... - 80% have fever ... - ACS, AKI, acute ... WBC >100k, + lab signs ... : • Pathophysiology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
survival is 93-95% Pathophysiology ... and progressive Acute ... rarely preceded by acute ... : ACUTE, fever, ... Diagnosis #Management #Signs
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... Diagnosis: HLH signs ... presents as an acute ... following: • Fever ... management #treatment #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Richter’s Syndrome ... Transform to DLBCL, PML ... ’s lymphoma or acute ... leukemia • Sezary syndrome
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