28 results
Rodent-associated Bacterial infections: Leptospirosis, Rat-bite fever, Tularemia, Plague 

#rodent
#infections
#leptospirosis
#tularemia
#ratbitefever
#plague
#rats
#infectiousdisease
#fever
#differential
#diagnosis
#management
#treatment
#table
Leptospirosis, Rat-bite fever ... plague #rats #infectiousdisease ... #fever #differential ... #diagnosis #management ... #treatment #table
Immune Checkpoint Inhibitor Toxicity

Main Toxicities: Colitis,  
Pneumonitis, Skin adverse events, Endocrine dysfunction, 
Hepatitis,  
Myocarditis,
Immune Checkpoint ... Inhibitor Toxicity ... Complications and Treatment ... #SideEffects #Table ... #Diagnosis #Pharmacology
Adjuvant therapies in critical care: steroids to treat infectious diseases
 - Severe Community Acquired Pneumonia
Pneumonia - Typhoid fever ... respiratory distress syndrome ... Corticosteroids #Adjuvant #InfectiousDiseases ... #Infections #Pharmacology ... #Management #Treatment
Back to the "10 Need to Know" series - Drug Therapeutic Target Levels. 

For lithium, target
vary depending on treatment ... mortality at a higher level ... Ranges #Toxicology #Pharmacology ... #Diagnosis #Table
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Induced Muscle Toxicity ... , immune-mediated ... Atorvastatin Diagnosis ... Statin #muscle #toxicity ... #myopathy #diagnosis
Hantavirus
Pathogen: Hantavirus - Rodents are the primary reservoir
Transmission:
 • Shed in the urine, feces, saliva of
Cardiopulmonary Syndrome ... • Prodrome: fever ... +/- diarrhea Diagnosis ... #management #treatment ... #microbiology #infectiousdiseases
Visceral Leishmaniasis - Diagnosis and Management Summary
Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi
Where: South Asia, East
cell-mediated immune ... 2-6 months • Fever ... culture, PCR, K39) Treatment ... #management #treatment ... #infectiousdiseases
Therapeutic Drug Level Monitoring 
Carbamazepine - Sample immediately before next dose (trough) 
Clozapine - Sample immediately
Therapeutic Drug Level ... at anytime if toxicity ... Sample trough level ... Ranges #Toxicology #Pharmacology ... #Diagnosis #Table
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... underlying genetic immune ... following: • Fever ... • Bicytopenia Treatment ... #management #treatment
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
mutations) • Immune ... HCV - HIV • Immune ... index < 2 • EPO Level ... aplastic anemia Treatment ... oncology #hematology #diagnosis