31 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
• Clinical: fever ... , ↓ Fibrinogen level ... CMV, HHV8,...), Bacteria ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
can mimic common infections ... Treatment: • Infection ... rapidly, and empiric antibiotic ... #management #treatment ... #hematology
Rodent-associated Bacterial infections: Leptospirosis, Rat-bite fever, Tularemia, Plague 

#rodent
#infections
#leptospirosis
#tularemia
#ratbitefever
#plague
#rats
#infectiousdisease
#fever
#differential
#diagnosis
#management
#treatment
#table
Rodent-associated Bacterial ... infections: Leptospirosis ... differential #diagnosis ... #management # ... treatment #table
Antibiotic Therapy for Spontaneous Bacterial Peritonitis  (SBP)

- Standard therapy 
- Uncomplicated SBp• 
- Nosocomial SBP
Antibiotic Therapy ... for Spontaneous Bacterial ... renal failure #Management ... #Regimen #Pharmacology ... #Hepatology
Suspected catheter-related bloodstream infection - Management Algorithm
 • Temperature 37.8 C   • Rigors
Antibiotic Management ... Hemodynamically stable ... Antibiotic Management ... • Persistent fever ... #CRBSI #diagnosis
Spontaneous Bacterial Peritonitis (SBP) - Diagnosis and Management
Ascites PMN > 250/mm3
? Nosocomial or hospital acquired. Recent
Spontaneous Bacterial ... Peritonitis (SBP) - Diagnosis ... dysfunction or liver ... #Spontaneous #Bacterial ... #Management #hepatology
Conditions Associated With Hyperferritinemia 
DDx of extreme hyperferritinemia >10,000
Not just HLH - in fact, most common
Liver disease 3. ... - Malignancy—Hematologic ... Hemoglobinopathy - Infection-Bacterial ... (Babesia) - Diagnosis ... #differential #diagnosis
IDSA Recommendations for Preventing and Treating Bacterial Enteric Infections in HIV-AIDS
Preventing Bacterial Enteric Illness:
 • Antimicrobial
IDSA Recommendations ... depending on their level ... #IDSA #Prevention ... #Treatment #management ... #HIVAIDS #pharmacology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
lymphohistiocytosis (HLH ... SLE], AOSD) • Infection ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
Flutycosine - Antibiotics ... B for initial management ... - Virtually never ... adverse effects = Hematologic ... #Pharmacology #Antibiotics