Flutycosine - Antibiotics Class Overview - Mechanism: 5-FC interferes with DNA and protein synthesis. Only available PO in the US - Used in combination with Amphoterecin B for initial management of several severe fungal infections: Severe cryptococcal pneumonia and meningitis, severe candidal infections (endocarditis, meningitis) - Virtually never used as monotherapy due to high incidence of primary and acquired resistance (monotherapy reserved for non-severe candida urinary tract infections) - Main adverse effects = Hematologic (Leukopenia and Thrombocytopenia) and Hepatic toxicity. - Drug levels should be monitored to reduce toxicity. #Pharmacology #Antibiotics #Review #Overview #Flutycosine #Antifungal
