2489 results
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... , ↓ Fibrinogen level ... Unknown cause Treatment ... #management #treatment
5-Oxoprolinuria
What is it:
 • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle
 • Amino acid transport and
paracetamol ingestion Clinical ... HAGMA; Paracetamol level ... high index of clinical ... Oxoprolinuria #diagnosis ... #management #treatment
Algorithm for Management of Acute Exacerbation of COPD (AECOPD)

Obtain workup for alternate diagnoses and relevant comorbidities:
for alternate diagnoses ... CBC, vitamin D level ... deficiency for newly diagnosed ... of AECOPD: • Clinical ... #Exacerbation #treatment
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
Lung Abscess - Diagnosis ... Lung Abscess - Clinical ... : • 80% have fever ... decubitus - air fluid level ... hemorrhage • Treatment
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
brain PRES Clinical ... elevated protein level ... persistent altered level ... epilepticus Treatment ... underlying cause • Treatment
How to use C-reactive protein (CRP)- Review https://ep.bmj.com/content/early/2018/07/19/archdischild-2018-315079

 - An CRP alone cannot be used to
biomarker the clinical ... attending ED the CRP level ... demonstrates a poor diagnostic ... guide intial treatment ... Peds #Pediatrics #Diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
syndromes Clinical ... is the main clinical ... ALT ↑ bilirubin level ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
of a previously diagnosed ... No specific diagnostic ... decrease in HIV-1 RNA level ... noncompliance • Clinical ... initiation Clinical
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
intrinsic factor, IF) Clinical ... - Low Vit B12 level ... Check for IF ab Treatment ... several days, Hb level ... consider other diagnosis
Community Acquired Pneumonia (CAP) - Diagnosis and Management

Pneumonia Signs/Symptoms:
 • Confusion/disorientation (LR + 1.9)
 • Cough
Pneumonia (CAP) - Diagnosis ... urea nitrogen level ... aeruginosa Clinical ... procalcitonin level ... Treatment: