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Lung Infections in HIV - Differential Diagnosis Framework

Disease by CD4 Count:
Any CD4 Count:
 • Mycobacterium tuberculosis,
loss, lethargy, fever ... • Fever, weight ... Cytopenias VIRAL ... Abdominal pain, chronic ... Infections #HIV #AIDS #pulmonary
Cavitary Lung Disease - Differential Diagnosis and Workup Algorithm
Acute / Subacute:
 • Acute Infections: Lung abscess,
Workup Algorithm Acute ... Subacute: • Acute ... abscess, Necrotizing Pneumonia ... Fungal, Parasitic, Viral ... Algorithm #lesion #pulmonary
Causes of Cough and Hemoptysis
Acute Inflammation 
 - Laryngitis 
 - Tracheobronchitis 
 - Mycoplasma and
and Hemoptysis Acute ... Mycoplasma and Viral ... Pneumonias - ... Bacterial Pneumonias ... Cancer of the Lung
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
104°F) • Lobar pneumonia ... gram-negative pneumonia ... • Acute bacterial ... infections • Acute ... or lung abscess
Fever in Returning Travelers from Tropical Regions - Frequent Differential Diagnoses
Medical History:
 • Skin exposure to
, acute HIV infection ... Cough, dyspnea - Pneumonia ... melioidosis, typhoid, pulmonary ... eosinophilia - Tropical pulmonary ... , Lassa fever, acute
Interstitial pneumonias
An acute reticular pattern is most frequently caused by interstitial edema due to cardiac heart
An acute reticular ... : Viral PCP Mycoplasma ... cough and some fever ... #Clinical #Radiology ... #CXR #Acute #Interstitial
Approach to Eosinophilic Lung Diseases
 • Acute Eosinophilic Pneumonia (< 1 wk) - ~30yo, M; Recent
Diseases • Acute ... initiation of smoking; Fever ... brown sputum, fever ... Travel hx, food hx; Fever ... #Diseases #pulmonary
Based on the images alone, it is usually not possible to determine the cause of the
or chronic illness ... , clinical data ... with cough and fever ... with low oxygen level ... nodular interstitial lung
Cryptogenic Organizing Pneumonia (COP)

Cryptogenic Organizing Pneumonia Overview:
 • Idiopathic form of organizing pneumonia
 • formerly BOOP
- Clinical manifestations ... cough, dyspnea, fever ... , Chronic eosinophilia ... pneumonia, Pulmonary ... #COP #BOOP #pulmonary
Non-Resolving Pneumonias: Etiologies
Unusual Infections:
 - Immunocompromised patients (e.g.: Mycobacterium, Aspergillosis, Nocardia)
 - Endemic Fungi (e.g.: Histoplasmosis,
Non-Resolving Pneumonias ... yersinia/rats, Q fever ... Eosinophilic PNA (acute ... or chronic) ... #NonResolving #Pneumonia