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Germ Cell Layers and Derivatives Ectoderm • Neural Crest • Neural Tube • Surface Ectoderm Mesoderm Endoderm Sarah Lyon @sarahthelyon #Germ
Germ Cell Layers ... Ectoderm Mesoderm Endoderm ... sarahthelyon #Germ #Cell
Cells, Molecules, and Therapies. Shown is a simplified schematic depiction of major cell types within white-matter
Cells, Molecules ... depiction of major cell ... DiseaseModifying #Targets #NEJM
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
cells can infiltrate ... disease • B cell ... AIHA • Pure red cell ... lymphoma • Hairy cell ... Smoldering adult T cell
Plasmacytomas and Plasma-Cell Leukemia - Physical examination revealed multiple exophytic subcutaneous lesions involving the arms and
Plasmacytomas and Plasma-Cell ... revealed 25% plasma cells ... Leukemia #Smear #NEJM
Inflammatory mechanism of asthma. Airway epithelial cells exposed to activation stimuli, including allergens, viruses, and irritants,
Airway epithelial cells ... promote dendritic cell ... activate naive CD4 T cells ... These T cells then ... induce B-cell class
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
Spur-Cell Anemia ... consistent with spur-cell ... Spur cells acquire ... Spur-cell anemia ... #NEJM #clinical
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Involvement - B-cell ... CD10 - T-cell ... or λ), Smudge Cells ... - B-cell ... Thrombocytosis - T-cell
Cellular and humoral immune responses of the adaptive immune system. Activated T cells accomplish cellular immune
Activated T cells ... responses, and B cells ... antigen activates B cells ... binding to the B-cell ... binding to the T-cell
B/T Cell Development This is a work in progress describing the maturation of B & T cells
B/T Cell Development ... maturation of B & T cells ... more to the T cells ... #lymph node #b-cell ... #t-cell
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
of ALL is of B-cell ... lymphadenopathy • Blast cells ... organs When Cancer Cells ... Hypogammaglobulinemia, smudge cells ... form of large cell
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