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diagnosis oncology hemolytic agglutinin algorithm atlas bloodcell causes disease disorders gap globulin hodgkins leukemia lymphoma management mds microscopy monoclonal morphology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC) Morphology Microcytic ... Agglutinate: Cold ... , Paroxysmal cold ... RBC #Morphology #differential ... #diagnosis #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
is of B-cell lineage ... - infiltrates (anemia ... bone marrow and secondary ... -> Invade Skin: ... #Leukemia #Hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
AIHA Primary Secondary ... lymphoproliferative disorder Secondary ... • Symptoms of anemia ... younger pts) Differential ... #hematology #diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold ... Diagnosis #Algorithm #workup ... #hematology #testing
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... practices that could ... changes), high MCV anemia ... not required in all ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... just beneath the skin ... Rule Out Secondary ... blood count with differential ... Syndromes #diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... (-) hemolytic anemia ... due to cold IgG ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... Immune hemolytic anemia ... Hodgkin Lymphoma Workup ... Immunohistochemical studies (to differentiate ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gammopathy, and skin ... gastric tumors • Hematology ... anemia • Other ... #diagnosis #hematology
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