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hematology oncology treatment apml cvid differential differentiation erythematosus gap globulin hemophagocytic hepatopulmonary hlh hypogammaglobulinemia immunodeficiency immunology lupus lymphohistiocytosis macrophage mas
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Chronic lung ... autoimmune hemolytic anemia ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... with leukopenia, anemia ... #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... • Incidence: common ... Imaging: CXR- pulmonary ... Differentiation #Syndrome ... #management #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
hematopoiesis cell lineages—erythrocytic ... Most common cytopenia ... : Macrocytic anemia ... with single-lineage ... #diagnosis #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... symptoms can mimic common ... #management #treatment ... #hematology
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... absence of intrinsic lung ... • Dyspnea - Common ... #diagnosis #management ... #treatment #hepatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... lymphopenia, low PLT • Anemia ... Kidney disease common ... Chronic B-cell activation ... #Rheumatology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... ovarian tumors, lung ... gastric tumors • Hematology ... Comment on type ... #hematology
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