9 results
Key Characteristics of Old and New Potassium-Binding Agents

- Dr. Edgar V. Lerma https://twitter.com/edgarvlermamd

#Potassium #Binding #KBinders #Kayexelate
New Potassium-Binding ... KBinders #Kayexelate #Comparison ... #Table #Pharmacology ... #Patiromer #HyperKalemia ... #Nephrology #Agents
Potassium-Binding Agents to Treat Hyperkalemia
Sodium zirconium cyclosilicate (Lokelma):
 • Mechanism: Preferentially captures K in exchange for
Potassium-Binding ... 10 g QD (adjust dose ... aspiration #Potassium #Binding ... #pharmacology #table ... #comparison #binders
Phosphate binders - quick reference chart of maximum daily dose. Most patients with CKD will require
maximum daily dose ... require phosphate binding ... since they are not able ... restricted due to hypercalcemia ... Only* #CKD #Nephrology
Opioid Use Disorder Medications - Pharmacokinetics

Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
activity, high binding ... in which higher doses ... the sublingual tablet ... Pharmacokinetics #Comparison ... #Table #Pharmacology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Elimination (see Table ... Transient, repeat dose ... Treatments: • K-Binding ... (10g PO tid) - caution ... Treatment #potassium #nephrology
Sedative-Hypnotic Drugs
Benzodiazepines:
 - Bind to specific GABAA receptor subunits at central nervous system (CNS) neuronal synapses
hyperpolarization - Dose-dependent ... GABAA receptors, acting ... Antagonists: - Blocks binding ... #pharmacology #comparison ... #table
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
normal volume-based algorithm ... diuresis) RAAS Active ... : Hypovolemia, Hypervolemia ... differential #diagnosis #table ... #sodium #nephrology
Pragmatic diagnostic algorithm for hypokalemia. 
***Typical presentations: 
 • Vomiting: urine Na/Cl > 1.6, low urine
Pragmatic diagnostic algorithm ... urine Cl; • Active ... severe to the dose ... #differential #algorithm ... #nephrology
Management of Pruritus in Patients with Chronic Kidney Disease
Pruritus with no primary lesions - differential diagnosis:
Dove sensitive skin ... to TID • For localized ... BID-QID (onset of action ... Pruritus #Treatment #Algorithm ... Uremia #Management #Nephrology