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diagnosis management pulmonary infectiousdiseases activetb causes coccidioidomycosis comparison fungal pharmacology tuberculosis abscess agents aids algorithm antifungal antifungals aspergillus betadglucan biomarkers
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Lymphoma • Lung ... Septic emboli • Lung ... • Progressive lung ... • Upper lobe lung ... characteristic features Clinical
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
• Lymphoma • Lung ... Septic emboli • Lung ... • Progressive lung ... • Upper lobe lung ... characteristic features Clinical
Chronic Cough - Differential Diagnosis Algorithm Red Flags: • Fever, night sweats, chills (infection) • Weight loss,
(infection) • ... Dyspnea (underlying lung ... disease or CHF) ... ) • Abnormal CXR ... History of cancer, lung
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
polymicrobial infection ... Lung Abscess - Clinical ... Blood cultures • CXR ... Cryptococcus - Coccidioides ... westermani • Other: TB
Pulmonary Infections in HIV-AIDS Bacterial: • No organism identified, Strep pneumoniae, H. influenzae, S.aureus, Streptococcus Grp
Endemic fungi (Coccidioides ... failure, COPD, Lung ... Evaluation: Imaging (CXR ... Fungal, AFB), TB ... diagnosis #evaluation #differential
Lung Infections in HIV - Differential Diagnosis Framework Disease by CD4 Count: Any CD4 Count: • Mycobacterium tuberculosis,
Lung Infections ... macrophages in HIV • Lung ... Pneumonia: • Upper lung ... cough, myalgia • Lung ... Microsporidium #Lung
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
status • Chronic lung ... to NTM: Chronic lung ... Kansasii: • Mimics TB ... - Cough and lung ... #differential #
Bronchiectasis - Summary What? • Bronchiectasis is derived from the Greek words bronckos meaning airway and ectasis meaning
: TB, NTM, PNA ... in the adjacent lung ... of the affected lung ... mycobacteria Treatment ... Bronchiectasis #pulmonary #differential
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
has five major clinical ... fungal stain of clinical ... change in the lungs ... • Serology for Coccidioides ... nails, bronchi, lungs
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan Beta-D-Glucan: • Polysaccharide cell wall component of many fungi • Pathogens:
dermatophytes, Coccidioides ... cut-offs defined in clinical ... BAL GM does not differentiate ... Clav (may be + as long ... setting of GVHD) ID
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