42 results
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... - Diuretic Sites ... urearetics) 3) Loop ... Adenosine #Nephron ... #Pathophysiology
Nephron Remodeling as a Mechanism of Diuretic Resistance. When high doses of loop diuretics are used
Nephron Remodeling ... a Mechanism of Diuretic ... high doses of loop ... diuretics are used ... #Pathophysiology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Acting on the Nephron ... - Diuretics and ... mannitol) 3) Loop ... spironolactone) #Pathophysiology ... #Nephrology #Nephron
Flowchart to diuretic use in acute heart failure.

(A) Congestion with volume overload. 

(B) Treatment algorithm after
(B) Treatment algorithm ... Total loop diuretic ... maximal dose for IV loop ... following a single loop ... #CHF #Algorithm
Diuretics - Pharmacology

Thiazides diuretics:
 • Inhibit Na+ Cl- cotransporter in distal tubule
 • Chlorothiazide, Chlorthalidone, Indapamide,
Metolazone Loop ... loss through the nephron ... Pharmacology #nephrology #conversion ... #loop #thiazide ... #classes
Mechanisms of Loop Diuretic Action and Resistance. Panel A, loop diuretics circulate bound to protein. As
Mechanisms of Loop ... Diuretic Action ... Panel A, loop diuretics ... #Pathophysiology ... #Nephro #IM #LoopDiuretic
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... plasma insulin (treatment ... anhydrase inhibitors, loop ... syndrome (mimics loop ... #Hypokalemia #Causes
Hyponatremia Treatment Algorithm

CHF, Cirrhosis - Fluid restriction
SIADH - Fluid restriction
 - Consider salt tablets if etiology
Algorithm CHF ... consider adding loop ... diuretic Reset ... -> free water diuresis ... #Algorithm #Management
Cyanide Toxicity 
Treatment:
1) Hydroxocobalamin + Cyanide = Cyanocobalamin (nontoxic) 
   or 
2) Amyl nitrite
Cyanide Toxicity Treatment ... Amyl nitrite - causes ... thiosulfate enhances conversion ... Toxicity #Toxicology #Pathophysiology ... #Management #Treatment
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Differential Diagnosis Algorithm ... Remote use of loop ... pressure: Active diuretic ... Differential #Diagnosis #Algorithm ... #causes #urinary