8 results
Mechanisms of Loop Diuretic Action and Resistance. Panel A, loop diuretics circulate bound to protein. As
Mechanisms of Loop ... Diuretic Action ... Panel A, loop diuretics ... #Pathophysiology ... #Nephro #IM #LoopDiuretic
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Algorithm - Urinary Chloride ... Remote use of loop ... or thiazide diuretics ... , Congenital chloride ... blood pressure: Active
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... Remote use of loop ... or thiazide diuretics ... blood pressure: Active ... diuretic use, Bartter
Nephron Remodeling as a Mechanism of Diuretic Resistance. When high doses of loop diuretics are used
a Mechanism of Diuretic ... high doses of loop ... diuretics are used ... #Pathophysiology ... #Nephro #IM #LoopDiuretic
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
vomiting/ nasogastric suction ... • Thiazide or loop ... diuretics after ... renal tubule diuretic ... • Thiazide or loop
Causes of Hypokalemia
Transcellular Shifts:
 - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Transcellular Shifts: - Alkalosis ... plasma insulin (treatment ... , nasogastric suction ... anhydrase inhibitors, loop ... syndrome (mimics loop
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... • Metabolic alkalosis ... +2Cl- Symport (Loop ... the Nonspecific Cation ... Tolvaptan) • Treatment
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
with thiazide diuretic ... Hypochloremic metabolic alkalosis ... Surreptitious diuretic ... Rhabdomyolysis Treatment ... nephrology #management #pathophysiology