9 results
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... Malnutrition • Wilson's disease ... deficiency • blood ... collection with EDTA Pathophysiology ... Hyophosphatasia #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... organ damage Clinical ... • Severe Liver Disease ... #Coagulation #diagnosis ... #management #hematology
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
ALP, alkaline phosphatase ... alcohol-related liver disease ... mellitus; USS, ultrasound ... Abnormal #Algorithm #Hepatology ... Liver #Enzymes #Differential
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
= nonspecific (nausea ... rapidly develops (DIC ... Antithrombin Ill • Ultrasound ... infiltration) Differential ... Liver #Pregnancy #hepatology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
which can plug blood ... : • + Clinical ... cryoglobulins • Negative causes ... skin necrosis • DIC ... #rheumatology #hematology
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
pain, dark urine, DIC ... Causes purpura & ... Malaria, Borrellia (Lyme ... #Transfusion #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
pain, dark urine, DIC ... Causes purpura & ... Malaria, Borrellia (Lyme ... #Transfusions #diagnosis ... #management #hematology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... of peripheral blood ... • Autoimmune diseases ... #WBC #CBC #hematology ... #pathophysiology
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Hodgkin Lymphoma - Clinical ... Workup: • Full Blood ... Immunohistochemical studies (to differentiate ... number of sites of disease ... classification #hematology