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diagnosis differential oncology management chronic leukemia lymphocytic cvid gap globulin hemeonc hemolytic hodgkins hypogammaglobulinemia immunodeficiency immunology lymphoma lymphomas lymphoproliferative mds
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... can indicate disease ... lymphoproliferative disorders ... • Neutropenia, anemia ... #oncology #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Leukemia (CLL) ... leukemia in adults • Disorder ... Transformation to large cell ... uw_IMresidency #CLL ... Leukemia #oncology #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders ... - T Cell ~10% ... - B-Cell ~90% ... #Classification ... pathophysiology #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach ... Diagnosis Algorithm ... Disease • Marrow ... #Classification ... #Causes #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... • Sickle cells ... Consider sickle cell ... Consider RBC membrane disorder ... #workup #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Most common cytopenia ... Myeloproliferative Disease ... Syndromes #diagnosis #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... (NSHL) - (most common ... Hodgkin Lymphoma Workup ... number of sites of disease ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... to impaired B-cell ... Granulomatous lymphocytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Too many cells in ... Better call hematology ... , think about common ... a good idea to call ... #workup #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... myeloma • Plasma cell ... gastric tumors • Hematology ... Thalassemia, Sickle cell ... differential #diagnosis #hematology
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