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diagnosis oncology differential management chronic leukemia lymphocytic cell cvid gap globulin hodgkins hypogammaglobulinemia immunodeficiency immunology lymphoma lymphoproliferative mds myelodysplasia myelodysplastic
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
leukemia in adults • Disorder ... lymphoma (Richter ... chemotherapy for low-risk disease ... Leukemia #oncology #hematology ... #hemeonc #diagnosis
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
: • Most common ... cells can indicate disease ... lymphoproliferative disorders ... • Neutropenia, anemia ... #oncology #hematology
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Disorders - Differential ... Diagnosis Algorithm ... symptoms not as common ... #Classification ... pathophysiology #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Overall Approach ... Diagnosis Algorithm ... Disease • Marrow ... #Classification ... #Causes #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... ) Classification ... Workup: • Full ... number of sites of disease ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... hepatitis • Lymphoma ... Granulomatous lymphocytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... Most common cytopenia ... Myeloproliferative Disease ... Syndromes #diagnosis #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... gastric tumors • Hematology ... anemia • Other ... Comment on type ... differential #diagnosis #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Biopsy: Solitary disorder ... • No CRAB - no anemia ... IFE, FLC assay Pathology ... • Non-Hodgkin Lymphoma ... #Hematology
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