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hemolytic leukemia chronic cll lymphocytic workup algorithm aplastic atlas causes classification cold common cvid extravascular gap globulin hemeonc hodgkins hypogammaglobulinemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... . primary cold agglutin ... Hemoglobinopathies (e.g. sickle ... Extravascular #Causes #differential ... #diagnosis #hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Agglutination - Cold agglutinins ... #Anemia #Differential ... #workup #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
- Sickle cell anemia ... uremic syndrome ... Morphology #Atlas #key #diagnosis ... #differential # ... hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... Viral Infection Clinical ... Diagnosis: • hemolytic ... #disease #hemolytic ... #anemia #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Hemoglobin Defects: Sickle ... cell anemia, Thalassemias ... Diagnosis #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
immunophenotype Clinical ... chemotherapy for low-risk disease ... #Leukemia #oncology ... #hematology #hemeonc ... #diagnosis #management
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
purple, hemorrhagic skin ... anemia - Splenomegaly ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... Hepatomegaly • Skin ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... - infiltrates (anemia ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Coombs (-) hemolytic ... anemia due to cold ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
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