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chronic cll common differential hlh hypogammaglobulinemia icl idiopathic immunodeficiency immunology leukemia lymphocytic lymphocytopenia lymphohistiocytosis lymphopenia oncology sjogrens summary treatment variable
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
surface molecules: CD5 ... • Richter’s Syndrome ... #Leukemia #diagnosis ... #workup #oncology ... #hematology
Idiopathic CD4 Lymphopenia (ICL) / Lymphocytopenia DIAGNOSTIC CRITERIA FOR ICL • Persistent CD4 T-cell lymphopenia •
Idiopathic CD4 Lymphopenia ... • Persistent CD4 ... mL or 20% total lymphocyte ... #hematology #Differential ... #Causes #lymphocytopenia
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
(HLH) Pathophysiology ... →Activation of CD8 ... Drugs, Unknown cause ... #management #treatment ... #summary #rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Granulomatous lymphocytic ... DDX - Other causes ... : • Nephrotic syndrome ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
glands: • Focal lymphocytic ... Hypocomplementemia • Can cause ... /aggregate) of CD4 ... #Rheumatology # ... Diagnosis #Management
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