10 results
Causes of Severe Acute Liver Injury
 - Ichemic hepatitis
 - Acute biliary obstruction
 - Drug-Induced liver
- Acute biliary ... - Autoimmune ... hepatitis - Wilson ... disease - Hemochromatosis ... - Primary biliary
Clinical Examination for Liver and Biliary Diseases
1) Hands: Clubbing, Dupuytren's contracture, Leuconychia, Bruising, Flapping tremor (hepatic
for Liver and Biliary ... erythema 2) Face: Jaundice ... Xanthelasma and jaundiced ... Kayser-Fleischer rings in Wilson's ... #physicalexam #
Common Etiologies of Cirrhosis

Inflammation

 - Hepatitis B (15 percent)

 - Hepatitis C (47 percent)

 - Schistosomiasis
Inflammation - Hepatitis ... 15 percent) - Hepatitis ... Schistosomiasis - Autoimmune ... congenital - Primary biliary ... - Wilson disease
Hepatomegaly - Differential Diagnosis Algorithm
Malignant
 • Primary Carcinoma
 • Metastases
 • Lymphoma
 • Leukemia
 • Polycythemia
Hemochromatosis • Wilson's ... Disease • Amyloidosis ... • Autoimmune ... Hepatitis • Drug ... Cholangitis • Primary Biliary
Clinical Diagnosis of Autoimmune Hepatitis
 - Onset of jaundice within prior 8 weeks
 - Ongoing consumption
Clinical Diagnosis of Autoimmune ... Hepatitis - Onset ... of jaundice within ... (Wilson disease ... SMA >1:80 #Autoimmune
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Hemochromatosis, Wilson's ... Disease, Alpha- ... Other: NAFLD, Autoimmune ... biliary obstruction ... Extrahepatic • Biliary
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
• Ischemia • Autoimmune ... • Wilson's ... • Cholestatic disease ... • Alcoholic hepatitis ... Duct Stone • Biliary
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary ... Pathophysiology: • T lymphocyte ... hyperpigmentation • Jaundice ... but elevated as disease ... Diagnosis: • Viral hepatitis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Metabolic/Hereditary: Wilson ... • Autoimmune: ... Autoimmune hepatitis ... Extrahepatic - Biliary ... - Obstruction: Biliary
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... glands: • Focal lymphocytic ... UIP, NSIP): • Lymphocytic ... hepatitis, primary ... biliary cirrhosis