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diagnosis hematology differential causes dermatology generalized leukemia pruritus secondary workup cll common cvid diffuse hypogammaglobulinemia immunodeficiency immunology lymphadenopathy management mds
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Reactive: - Systemic ... Age > 50 • Chronic ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... rendering the immune system ... cells can indicate disease ... diagnosis #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis Algorithm ... Cholestatic liver disease ... Creatinine & BUN: • Chronic ... Myelodisplastic syndrome ... Psychiatric Disease
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Autoimmunity • Chronic ... Granulomatous lymphocytic ... hemolytic anemia) • Systemic ... : • Nephrotic syndrome ... Malignancies • Chronic
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... Autoantibodies: • WAIHA • CAD ... Sneddon-Wilkinson disease ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Cholestatic liver disease ... Creatinine & BUN: • Chronic ... Myelodisplastic syndrome ... Psychiatric Disease ... Pruritus #secondary #systemic
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... frequently affected systems ... normal/high - Chronic ... can drive this disease ... As with many disease
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Marrow Failure • Chronic ... Myeloproliferative Disease ... compounds, alcohol, lead ... #diagnosis #hematology ... #oncology
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