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diagnosis hematology differential management causes dermatology generalized leukemia pruritus abnormal activation chronic cll common cvid enzymes hemeonc hemophagocytic hlh hypogammaglobulinemia
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
rendering the immune system ... cells can indicate disease ... ’s CLL Scoring system ... diagnosis #workup #oncology ... #hematology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Differential Diagnosis Algorithm ... Cholestatic liver disease ... Myelodisplastic syndrome ... Psychiatric Disease ... Pruritus #primary #secondary
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Classified among the secondary ... highly inflammatory disease ... Histopathologic criteria ... Diagnosis #Management #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... develop leukostasis syndrome ... • Tumor lysis syndrome ... bone marrow and secondary ... #Oncology #Diagnosis
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
infection risk secondary ... Granulomatous lymphocytic ... hemolytic anemia) • Systemic ... : • Nephrotic syndrome ... (Epstein-Barr syndrome
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Cholestatic liver disease ... Myelodisplastic syndrome ... Psychiatric Disease ... #Pruritus #secondary ... #systemic #generalized
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... urgent referral to secondary ... presence of metabolic syndrome ... criteria should ... #Hepatology #Liver
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
of the immune system ... STX11, STXBP2 • Secondary ... ▪ Autoimmune diseases ... Diagnostic Criteria ... of 8 HLH-2004 criteria
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