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rheumatology hlh lymphohistiocytosis treatment antinxp2 antinxp2dm classification cryoglobulinemia dermatology dermatomyositis differential hodgkins involvement leukemia lymphoma mds monoclonal myelodysplasia myelodysplastic nephrology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis Associated with : • Absence of skin
• Absence of skin ... min/1.73 m2 at diagnosis ... • Dialysis at diagnosis ... #Vasculitis #Management ... #Rheumatology #
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... involvement CML ... -> Invade Skin: ... #Leukemia #Hematology ... #Oncology #Diagnosis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... Evans • ITP • Cl-NH ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... sIL-2R >2400 Ul/ml ... Taar #HLH #Hemophagocytic ... #management #treatment ... #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... Low or absent NK cell ... Ferritin >500 ng/mL ... #management #treatment ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... amyloidosis, PAH Skin ... Nephrogenic DI Hematologic ... Vasculitis: • 7%, Cryoglobulinemia ... #Diagnosis #Management
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
low red blood cell ... just beneath the skin ... Myelogenous Leukemia (CML ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
accounts for 10% of all ... classical HL (MCHL ... lymph node biopsy (diagnostic ... classification #hematology ... #oncology #management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
have typical DM skin ... dorsal part of the MCP ... Dermatomyositis: • ILD was diagnosed ... Dermatomyositis #diagnosis ... #management #rheumatology
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