12 results
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... Arthralgia/arthritis, Skin ... fraction < 20% Differential ... Disease #diagnosis #management ... #treatment #rheumatology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... maculopapular skin ... Ferritin >3000 ng/mL ... #onset #Stills ... #management
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
Epidemiology: young adults ... Malignancies (eg CML ... NonHodgkins #comparison #oncology ... #diagnosis #differential ... #hematology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Epidemiology: • Young adults ... response to local skin ... Behcet disease) Differential ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Alpha & Mu) Skin ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology ... #Monoclonal #Differential ... #Diagnosis #Oncology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
sIL-2R >2400 Ul/ml ... diseases: SLE+++, Adult-onset ... Still disease, ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
arthritis (sJIA) • Adult-onset ... Still disease ... 5000 to 10,000 ng/mL ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... permanent alopecia Differential ... rheumatoid arthritis, adult-onset ... Still disease, ... Malignancy (e.g. hematologic
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
history • Young adults ... classical HL (MCHL ... Immunohistochemical studies (to differentiate ... classification #hematology ... #oncology #management
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
vasculitis in older adults ... very remarkable w/differential ... required due to skip ... them, but urgent rheumatology ... Symptoms #Diagnosis #Management