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diagnosis rheumatology allergy differential leukemia algorithm anemia aplastic cll dermatology disease eosinophilia erythematosus immunology lupus lymphocytic myelodysplasia pathergy polychondritis relapsing
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Syndromes (MDS) ... just beneath the skin ... Marrow Failure • Chronic ... Myelogenous Leukemia (CML ... #hematology #oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Oral aphthae : SLE ... • Arthritis: SLE ... Recurrent and chronic ... #management #signs ... #symptoms #rheumatology
Eosinophilia - Differential Diagnosis Algorithm Idiopathic Eosinophilia Primary Eosinophilia: • Primary hypereosinophilic syndrome • Eosinophilic Leukemia • MPN/MDS
Leukemia • MPN/MDS ... GI, lung, skin), ... IgG-4 disease, Behcet ... , Sarcoidosis, SLE ... insufficiency, Chronic
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... syndrome (MDS) ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
3rd Decade Skin ... Malignancy (e.g. hematologic ... Seizures • Strokes Skin ... La, anti-Jo-1, SCL ... with Lupus: • Chronic
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... non-Hodgkin lymphoma SLL ... Hepatomegaly • Skin ... diagnosis #workup #oncology ... #hematology
Pathergy Summary Overview What is pathergy? Pathergy is an exaggerated skin injury occurring after minor trauma such as
following: • Behcet ... (PG) • Sweet syndrome ... • Chronic myeloid ... leukemia (CML) ... positive if you see
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
• Inner ear • Skin ... cases such as: • SLE ... , MDS & Multiple ... Sarcoidosis • Behcet ... #diagnosis #management
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