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diagnosis rheumatology differential anemia aplastic behcet clinical dermatology disease erythematosus leukemia lupus manifestations mds monoclonal myelodysplasia paraproteinemias signs sjogrens symptoms
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
Cutaneous manifestations ... most frequent skin ... dermatomyositis, SLE ... #oncology #clinical ... #skin
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic ... Syndromes (MDS) ... just beneath the skin ... Myelogenous Leukemia (CML ... #hematology #oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
vasculitis) • Cutaneous ... Oral aphthae : SLE ... • Arthritis: SLE ... #diagnosis #management ... signs #symptoms #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... gangrenosum • Cutaneous ... thrombosis+Pulm HTN+skin ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... 3rd Decade Skin ... Malignancy (e.g. hematologic ... Seizures • Strokes Skin ... La, anti-Jo-1, SCL
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
violaceous, nontender cutaneous ... • Tumor lysis syndrome ... CLL -> Invade Skin ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Headaches • Pale skin ... • Hypocellular myelodysplastic ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Lacrimal swelling • Skin ... overlaps with RA, SLE ... ) • Cutaneous vasculitis ... Nephrogenic DI Hematologic ... Diagnosis #Management
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