13 results
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... With associated pulmonary ... Glomerulonephritis #Vasculitis #differential ... diagnosis #algorithm #rheumatology
TRALI vs TACO - Transfusion Reactions
TRALI:
 • Epidemiology: 0.1% of transfused patientsl
 • Risk factors: Critical
Risk factors: Critical ... blood donor • Pathophysiology ... without other cause ... , and CXR with pulmonary ... Transfusion #Reactions #hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Assessment • Clinical ... Drugs, Unknown cause ... treatment #summary #rheumatology
ANTI-MDA5 DERMATOMYOSITIS

Cutaneous manifestations:
• Periorbital heliotrope (blue-purple) rash with edema
• Erythematous rash on the face, or the
chest (in a V-sign ... dorsal part of the MCP ... Inverse Gottron’s sign ... auricular papules Clinical ... Dermatomyositis #rheumatology
Medial Meniscus Bucket Handle Tear - MSK Radiology
Imaging Findings:
 • Truncation of the medial meniscus on
sign" is seen on ... Case description ... Differential diagnosis ... BucketHandle #Tear #knee ... #mri #clinical
Gout (Gouty Arthritis) - MSK Radiology
Imaging Findings:
 • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
Case description ... mass and NO prior signs ... or clinical history ... Differential diagnosis ... diagnosis #msk #rheumatology
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... Behcet syndrome (Clinical ... Behcet disease) Differential ... diagnosis #management #signs ... #symptoms #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitides - Differential ... progressing GN • New pulmonary ... tract, and often causes ... purpura: strong sign ... #diagnosis #rheumatology
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... systemic sx + signs ... very remarkable w/differential ... them, but urgent rheumatology ... GCA #Temporal #Signs
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Vasculitis Differential ... purpura: Strong sign ... tract, and often causes ... #Diagnosis #Rheumatology