21 results
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... Hypochloremic metabolic alkalosis ... Hypocalciuria (spot ... ratio 0.5%) Differential ... nephrology #management #pathophysiology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Gitelman Syndrome ... H+ secretion → Hypokalemia ... Metabolic alkalosis ... #Syndrome #Pathophysiology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic Alkalosis ... - Differential ... , Gitelman Syndrome ... Primary #Metabolic #Alkalosis ... #Differential #
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... - Differential ... , Gitelman Syndrome ... aldosteronism #Metabolic #Alkalosis ... #Differential #
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Metabolic Alkalosis ... - Differential ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... #Differential #
Hypokalemia Differential Diagnosis Algorithm
Hypertensive:
 • High Al, Low R - Primary aldosteronism
 • High Al, High
Hypokalemia Differential ... Normotensive: • UCl ... , Gitelman's syndrome ... #Hypokalemia # ... Differential #Diagnosis
Causes of Hypokalemia - Differential Diagnosis Algorithm
Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... - Differential ... starts by measuring ... , Gitelman's syndrome ... #differential #
Hypokalemia Evaluation Algorithm

Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... Before evaluating hypokalemia ... - Metabolic Alkalosis ... , Gitelman syndrome ... diagnosis #Algorithm #differential
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine
Urine K+
patients with hypokalemia ... • Cell shift: Hypokalemic ... , Gitelman syndrome ... #hypokalemia ... urine #potassium #differential
Causes of Hypokalemia - Differential Diagnosis Algorithm
Increased Loss 
 - Increased GI Loss
 - Increased Urinary
Causes of Hypokalemia ... - Differential ... K-ATPase which imports ... - Refeeding Syndrome ... potassium #low #pathophysiology