26 results
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting, NGT
Primary Metabolic Alkalosis ... , Gitelman Syndrome ... , Liddle syndrome ... Primary #Metabolic #Alkalosis ... Diagnosis #Algorithm #nephrology
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... Gitelman Syndrome ... Hypokalemia Metabolic alkalosis ... #Syndrome #Pathophysiology
Primary Metabolic Alkalosis - Differential Diagnosis Algorithm
Volume Depleted - 2° hyperaldosteronism
 • Low Urine Cl-: Vomiting,
Primary Metabolic Alkalosis ... , Gitelman Syndrome ... , Liddle syndrome ... aldosteronism #Metabolic #Alkalosis ... Diagnosis #Algorithm #Nephrology
Localization of Renal Tubular Defects
Fanconi Syndrome: Proximal tubule
Bartter Syndrome: Thick ascending loop of Henle
Gitelman Syndrome: Distal
loop of Henle Gitelman ... Syndrome: Distal ... Fanconi #Bartter #Gitelman ... Nephron #Defects #Pathophysiology ... #Nephrology
Metabolic Alkalosis - Differential Diagnosis Algorithm - Urinary Chloride
 • Cl- responsive metabolic alkalosis
Metabolic Alkalosis ... responsive metabolic alkalosis ... Kidney loss of Cl ... diuretic use, Bartter syndrome ... , Gitelman syndrome
Approach to Elevated Bicarbonate (HCO3)
Risk Factors for Hypercapnea? (Hx of COPD, OSA, sedative use, CNS/muscular disorders?)
(+)
Likely Metabolic Alkalosis ... Contraction Urine Cl ... Barter, or Gitelman ... Syndrome Unremarkable ... Elevated #metabolic #alkalosis
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Metabolic Alkalosis ... Kidney loss of Cl ... diuretic use, Bartter syndrome ... , Gitelman syndrome ... urine #Algorithm #nephrology
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... Hypochloremic metabolic alkalosis ... Hypocalciuria (spot ... #nephrology #management ... #pathophysiology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
transporter Bartter syndrome ... ascending limb Gitelman ... syndrome - Thiazide-sensitive ... tubule Liddle syndrome ... Defects #Kidney #Nephrology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic Alkalosis ... /L • Gastric alkalosis ... furosemide-like lesion) • Gitelman ... #Metabolic #Alkalosis ... Diagnosis #Causes #nephrology