MDS - GrepMed

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An algorithm created for classifying MDS according to the new 2017 WHO Classification.

- Kyle Bradley, MD

for classifying MDS ... Kyle Bradley, MD ... Hemepath #HOnc #MDS

Dysplasia in Myelodysplastic Syndrome
-
Dysgranulopoiesis
- Dyserythropoiesis
- Dysmegakaryopoiesis

#Dysplasias #MDS #Myelodysplastic

#Dysplasias #MDS

Aplastic Anemia Summary

• Definition
• Pathophysiology
• DDx: AA vs Hypocellular MDS
• Expectation
•

vs Hypocellular MDS ... Zhuoer Xie, MD

Approach to Hypoproliferative Macrocytic Anemia

• 812, Folate Deficiency
• MDS+
• Hypothyroid
• Liver Disease

Deficiency • MDS ... Matthew Ho, MD

VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
• Common Clinical Features: alveolitis, ear and

myelodysplastic syndrome (MDS ... myelodysplastic syndrome (MDS ... Maheswaranathan, MD

Common RBC Inclusions and Associations
• Howell Jolly Bodies: Hyposplenism, Asplenism, Severe hemolytic anemia
• Heinz

, Sickle cell, MDS

Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
• Thalassemia

Reticulocytosis, MDS ... Matthew Ho, MD

Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells

Myelodysplastic Syndrome (MD ... Myelodysplastic #Syndrome #MDS

Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years

What?
• Aplastic anemia

myelodysplastic syndrome (MDS ... Hypocellular/Hypoplastic MDS ... abnormalities typical for MDS

Causes of Thrombocytopenia - Differential Diagnosis Framework
Decreased Production:
- Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,

infection (TB), MDS

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