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syndrome differential adult adultonset antinxp2 antinxp2dm aosd behcet dermatology dermatomyositis fungal immune infections infectiousdiseases inflammatory iris mycoses onset polychondritis reconstitution
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's ... • Ocular: uveitis ... #Disease #diagnosis ... #management #treatment ... #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
ulceration • Ocular ... Eye involvement (uveitis ... inhibitors • Uveitis ... #management #signs ... #symptoms #rheumatology
Adult Onset Still's Disease Systemic inflammation with urticarial rash. Rash: • Nonpruritic, evanescent (correlates with time of
Adult Onset Still's ... A nonpruritic macular ... #Adult #onset #Stills ... #diagnosis #rheumatology ... #management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... purpura (lower legs ... Uveitis, chorioretinitis ... interstitial keratitis, uveitis ... #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome Diagnosis ... gland) biopsy • Ocular ... phenomenon (16%) MSK ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Fever, cough, chills ... pulmonary symptoms • Rheumatologic ... Cough, fever, chills ... osteoarticular, pulmonary, ocular ... #Management #Infections
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
worsening of that disease ... skin lesions, ocular ... Zoster flare, ocular ... immune recovery uveitis ... #Management
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
chondritis • Ocular ... conjunctivitis, keratitis, uveitis ... /EGPA • RA Diagnosis ... Polychondritis #rheumatology ... #diagnosis #management
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Manifestations: Less ... But can still have ... had more severe disease ... Dermatomyositis #diagnosis ... #management #rheumatology
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