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diagnosis symptoms signs management differential cardiology endocrinology pharmacology nephrology syndrome infectiousdiseases complications msk causes lifecycle ophthalmology pulmonary cdc hematology hepatology
Type IV Hypersensitivity: Pathogenesis and clinical findings Definition: Unique because it is entirely T-Cell mediated; exposure to
typically a drug) -> Macrophage ... Cells activate macrophages ... Allergy #Immunology #pathophysiology
Leishmaniasis Life Cycle 1) Sandfly takes a blood meal (injects promastigote stage into the skin) Human Stages: 2) Promastigotes
phagocytized by macrophages ... meal (ingests macrophages ... LifeCycle #diagnosis #pathophysiology
Gaucher Disease Pathophsiology • Lysosomal storage disorder • Deficiency of ß-glucocerebrosidase • Accumulation of glucosylceramide in macrophages Diagnosis
Gaucher Disease Pathophsiology ... glucosylceramide in macrophages
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
neutrophils and macrophages ... #Inflammation #pathophysiology
Fever - Pyrogen Pathophysiology EXOGENOUS PYROGEN • Bacteria: Lipopolysaccharide components, peptidoglycans and muramyl peptide derivatives, Toxins •
Fever - Pyrogen Pathophysiology ... neutrophils, monocytes/macrophages ... Fever #Fever #Pathophysiology
Allergic Rhinitis: Pathogenesis and clinical findings 1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Exposure -> APC (macrophages ... , eosinophils, macrophages ... Rhinitis #Rhinorrhea #pathophysiology
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
killer cells, macrophages ... which activate macrophages ... Classification #Pathophysiology
Rigors And Bacteremia - Overview • Rigors are a response to the release of cytokines and prostaglandins
PATHOPHYSIOLOGY: ... Neutrophils, Monocytes/Macrophages ... Rigors #Bacteremia #Pathophysiology
Type II Hypersensitivity: Pathogenesis and clinical findings Definition: When antigens bind to the body's cell surfaces, forming
binding recruits macrophages ... Allergy #Immunology #pathophysiology
Tuberculosis Overview 10 million new M. tuberculosis infections/year Facultative intracellular rod-shaped bacteria Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
tuberculosis (LTBI) Pathophysiology ... by the alveolar macrophages ... Replication within macrophages ... IFN-γ-activated macrophages ... aggregation of macrophages
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