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oncology rheumatology hodgkins lymphoma management syndrome activation bandemia cbc chronic cll comparison erythematosus hemolytic lupus lymphocytic macrophage mds myelodysplasia myelodysplastic
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... inclusions - If infection ... bartonella (oroya fever ... Diagnosis #Algorithm ... #workup #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Lymphadenopathy • Fevers ... weeks without infection ... • Neutropenia, anemia ... #diagnosis #workup ... #oncology #hematology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
in vasculitic diseases ... inflammation or infection ... petechiae/purpura with fever ... #Diagnosis #Dermatology ... Purpural #Purpuric #Rash
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... sudden onset of a rash ... - Rash: multiple ... DDX: - Pyoderma ... #dermatology #oncology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
- Pel-Ebstein fever ... involved) • No leukemic ... translocation • Types: Classification ... lymphadenopathy, mass ... hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... ALL: mediastinal mass ... - infiltrates (anemia ... #Hematology #Oncology ... #Diagnosis
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Tissue damage • Leukemia ... • Autoimmune diseases ... tachycardia or fever ... #differential # ... #WBC #CBC #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Petechial or purpuric rash ... kidney failure DDX ... SLE], AOSD) • Infection ... with leukopenia, anemia ... #Management #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... fibromyalgia) • Infections ... lymphopenia, low PLT • Anemia ... Hodgkin lymphoma and leukemia
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out ... Myeloproliferative Disease ... blood count with differential ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
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