21 results
Adult-Onset Still's Disease (AOSD)
Rare inflammatory disorder of unknown etiology, difficult to diagnose because of heterogenous presentation.
Adult-Onset Still's Disease ... salmon-colored maculopapular ... rash, arthritis ... #AOSD #rheumatology ... #diagnosis #management
Algorithmic Approach to Anemia - Differential Diagnosis Framework by MCV

Microcytic (MCV < 80) "TAILS":
 • Thalassemia
Algorithmic Approach ... to Anemia - Differential ... Macroangiopathic, Infections ... Non-megaloblastic: Liver disease ... Diagnosis #hematology
Adult Onset Still's Disease
Systemic inflammation with urticarial rash.
Rash: 
 • Nonpruritic, evanescent (correlates with time of
nonpruritic macular or maculopapular ... mL Gf consider MAS ... #AOSD #diagnosis ... #rheumatology # ... management
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad: Fever ... arthritis, Skin rash ... Complications: MAS ... #diagnosis #management ... #treatment #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Diagnosis Algorithm ... inclusions - If infection ... bartonella (oroya fever ... Diagnosis #Algorithm ... #workup #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
lesions (9.4%) • Maculopapular ... reticularis Differential ... Polyangiitis #GPA #dermatology ... #rash #diagnosis ... #rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
kidney failure DDX ... ) • Infection ( ... with leukopenia, anemia ... #Management #Hematology ... #Rheumatology
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH 

These rashes can be especially challenging and are
associated with devastating differential
in vasculitic diseases ... inflammation or infection ... petechiae/purpura with fever ... #Diagnosis #Dermatology ... Purpural #Purpuric #Rash
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
may take 6 to 8 ... autoimmune hemolytic anemia ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Presentation: • Fever ... /fevers • Thrombocytopenia ... and thymoma DDX ... #oncology #hematology ... #diagnosis #management