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differential rheumatology dermatology algorithm classification diffuse erythematosus sle vasculitis activation cryoglobulinemia extravascular focal hair hemolysis hemolytic intravascular loss macrophage management
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm DIFFUSE Scarring - Irreversible-biopsy required • Lupus
) Differential Diagnosis ... • Loose anagen syndrome ... Diffuse #Focal #HairLoss ... #Alopecia #dermatology ... #Algorithm #causes
Allopecia - Differential Diagnosis Framework for Hair Loss Localized / Focal Hair Loss Pattern: • Scarring Alopecia:
Diagnosis Framework ... Disease: Discoid lupus ... , Loose anagen syndrome ... Vitamin D levels Systemic ... #dermatology #Hairloss
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cause Organ Damage ... Labs/Diagnosis: ... lupus erythematosus
Diffuse Hair Loss (Alopecia) - Differential Diagnosis Algorithm Scarring - Irreversible-biopsy required • Lupus erythematosus • Lichen
Irreversible-biopsy required • Lupus ... • Loose anagen syndrome ... stress #Diffuse #HairLoss ... #Alopecia #dermatology ... #Algorithm #causes
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Photosensitivity, Butterfly rash ... , Vasculitis, Purpura ... Demyelinating syndromes ... ) Blood (75%): Anemia ... signs #symptoms #diagnosis
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Diagnosis Algorithm ... Clotting factor deficiency ... Autoimmune Vasculitis (lupus ... immunoglobulins & cryoglobulins
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... thrombocytopenic purpura ... usually IgG) (e.g. lupus ... G6PD deficiency) ... #hematology #anemia
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... and permanent alopecia ... disease • Prolidase deficiency ... lymphopenia, low PLT • Anemia ... #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
lupus erythematosus ... rash) • Heart, ... with leukopenia, anemia ... #Diagnosis #Management ... #Hematology #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... mucositis - Rash ... lupus erythematosus ... Serologies for Cryoglobulins ... #rheumatology #
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