Maturation iron pathophysiology hematology cirrhosis dermatology hepatology classification morphology production

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Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
• Acute Bleed - Normocytic / Normochromic

MCH, MCHC, Serum Iron ... Decreased RBC Production ... Reticulocytes • Iron ... Non-lmmune #Anemia #Classification ... Algorithm #Causes #Hematology

Erythropoiesis (RBC Production and Maturation)

Pluripotent hematopoietic stem cell → Proerythroblast (a.k.a. pronormoblast) → Erythroblast (a.k.a. normoblast)

Erythropoiesis (RBC Production ... and Maturation) ... Erythropoiesis #RBC #Production ... #Maturation #hematology ... #pathophysiology

Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is

Reticulocyte Production ... x (Hct / 45) / Maturation ... Factor The maturation ... deficiencies: Iron ... #Index #hematology

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