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joint msk pain antibodies antinuclear approach autoimmune basophilia biliary causes cholangitis classification erythematosus gap globulin hepatology lupus monoarthritis monoarticular myopathy
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Basophilia - Differential ... Crohn’s Disease ... Other Causes: • Iron ... Irradiation • Cirrhosis ... #hematology #basophils
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
: The ANA patterns ... Patterns and Associated ... Primary Biliary Cirrhosis ... #patterns #rheumatology ... #diagnosis #differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology ... patients • +ANA ... bile ducts Differential ... #diagnosis #workup ... #hepatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... iron saturation ... #laboratory #workup ... #diagnosis #testing ... #Rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Differential Diagnosis ... • Is there a pattern ... asymmetric pattern ... #Diagnosis #MSK ... #rheumatology #
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
fever) and laboratory ... permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Non-autoimmune rheumatologic ... #Rheumatology
Approach to Joint Pain - Diagnostic Framework 1) Chronicity 2) Inflammatory vs Non-Inflammatory 3) Number of Joints Involved 1) Chronicity:
to Joint Pain - Diagnostic ... Joint #Pain #MSK #rheumatology ... #approach #workup ... #differential # ... diagnosis #arthritis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... Lab Tests: • CBC ... ) pattern: antibodies ... ) pattern: is usually ... #diagnosis #rheumatology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory ... hallmark for the disease ... from ischemia WBC ... count and differential ... #Workup #Hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... (RA, Temporal arteritis ... : Cirrhosis, ETOH ... gastric tumors • Hematology ... #diagnosis #hematology
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