16 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Positive ANAAutoimmune ... : The ANA patterns ... Primary Biliary Cirrhosis ... #patterns #rheumatology ... #diagnosis #differential
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... #rheumatology # ... approach #workup ... #differential # ... diagnosis #arthritis
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Differential Diagnosis ... • Is there a pattern ... Rheumatologic Disease ... Joint #pain #Differential ... #rheumatology #
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... patients • +ANA ... bile ducts Differential ... #diagnosis #workup ... #hepatology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Disease: • Pain ... #Pain #MSK #rheumatology ... #approach #workup ... #differential # ... diagnosis #arthritis
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
deficiencies: Iron ... Chronic kidney disease ... Production #Index #hematology ... #anemia #differential ... #diagnosis #calculation
Systemic Sclerosis (Scleroderma)
Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs
3
Multi-system autoimmune ... Musculoskeletal: joint ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... symptoms #testing #workup
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... iron saturation ... #laboratory #workup ... #diagnosis #testing ... #Rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... • Non-autoimmune ... rheumatologic diseases ... #Rheumatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
surfaces of the joints ... reticularis Differential ... • Giant cell arteritis ... with a certain pattern ... #rheumatology