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diagnosis differential management injury causes lfts transaminitis aclf autoimmune chemistry cirrhosis dili druginduced failure gastroenterology hbv hepatitisb hepatorenal hrs hyperlipidemia
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Hepatitis (AAH) ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology
Alcoholic Hepatitis - Management Algorithm 1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... survival in severe AH ... can be bridge to Liver ... #Algorithm #treatment ... #hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... 5-10x normal - Chronic ... #Patterns #Liver ... #Injury #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... HSV • Toxic: Alcohol ... , Acute biliary ... Medication, Pregnancy, Alcoholic ... #algorithm #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • NAFLD • Alcohol ... • Drugs • AIH ... hepatitis • Drugs ... Others #LFTs #Hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis Algorithm ... non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... dechallenge • Acute ... #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... and Management Algorithm ... Chronic Hepatitis ... #Management #Treatment ... #Hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... liver failure ... - Symptoms of chronic ... regarding need for treatment ... #Management #Hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Differential Diagnosis Algorithm ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
viral hepatitis ... ALT Ratios: • Alcoholic ... > 2 • NASH, Chronic ... injury: > 3 • Chronic ... #differential #Hepatology
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