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differential causes management hematology injury lfts transaminitis ascites cirrhosis deficiency hepatic oncology saag syndromes thrombocytosis aclf aih albumin anemia autoimmune
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... months without treatment ... Failure Infections Alcohol-Associated ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... > 20x normal - Acute ... 5-10x normal - Chronic ... #Injury #hepatology ... #differential #diagnosis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Diagnosis Hepatocellular ... HSV • Toxic: Alcohol ... Medication, Pregnancy, Alcoholic ... #Differential #Diagnosis ... #algorithm #hepatology
Alcoholic Hepatitis - Management Algorithm 1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... only increase short-term ... can be bridge to Liver ... #Algorithm #treatment ... #hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Algorithm DILI ... non-essential drug/HDS treatments ... HEV, EBV, CMV), Alcohol-related ... dechallenge • Acute ... #Algorithm #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Chronic Hepatitis ... #Algorithm #Diagnosis ... #Management #Treatment ... #Hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Cirrhosis • Chronic ... Viral Hepatitis ... Hepatopathy • Acute ... Viral Hepatitis ... #hepatology #transaminitis
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
- Differential Diagnosis ... Algorithm Malignant ... Non-Malignant • Fatty Liver ... Inflammatory • Alcoholic ... #Hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... - Differential Diagnosis ... Algorithm Severe ... hepatitis • Drugs ... Others #LFTs #Hepatology
Common Etiologies of Cirrhosis Inflammation - Hepatitis B (15 percent) - Hepatitis C (47 percent) - Schistosomiasis
Sarcoidosis Toxic - Alcohol ... Nonalcoholic fatty liver ... heart failure (chronic ... 14 percent) #Diagnosis ... #Differential #Hepatology
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