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diagnosis differential injury management alcoholic hematology syndrome dili druginduced eosinophilia gap globulin hepatorenal hiv hrs lfts liverenzymes nephrology protein proteingap
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... dechallenge • Acute ... steatosis • Autoimmune ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... hepatitis, Acute ... #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... Vascular Causes ... of Acute Liver ... : Autoimmune hepatitis ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... • Drugs • AIH ... • Alcoholic hepatitis ... #Causes
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... subclinical disease to acute ... regarding need for treatment ... #Hepatitis #AIH ... Diagnosis #Management #Hepatology
Alcoholic Hepatitis - Management Algorithm 1. Severity assessed not only by MDF (>32) but also by MELD
Alcoholic Hepatitis ... only increase short-term ... survival in severe AH ... can be bridge to Liver ... #treatment #hepatology
Causes of Eosinophilia - Differential Diagnosis Bugs: - Fungus (aspergillosis) - Viral (HIV) - Ectoparasites (scabies, myiasis)
- DRESS - AIN ... - Eosinophilic Hepatitis ... (vasculitis / autoimmune ... Mastocytosis - Acute ... #hematology
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... - Management Algorithm ... exclude other causes ... diseases including HBV ... #hepatology
Acute Retroviral Syndrome Acute Retroviral Syndrome is the symptomatic presentation of acute human immunodeficiency virus infection •
Hepatomegaly - Liver ... subset counts ↓ • Liver ... infection • Viral hepatitis ... Phase: • The short ... antibody test) Treatment
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Viral infections (acute ... HIV, HBV, EBV, ... Sarcoidosis) • Liver ... Cirrhosis, ETOH, autoimmune ... inflammation (acute
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