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diagnosis differential lupus treatment sle systemic dermatology ana antinuclear vasculitis antibodies classification hemophagocytic hlh lymphohistiocytosis summary joint pain patterns signs
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
infection • Lyme disease ... Vesicopustule on erythematous ... Antiphospholipid-antibody syndrome ... Discoid lupus erythematosus ... differential #diagnosis #rheumatology
ANA Patterns and Associated Rheumatic Diseases: • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
Associated Rheumatic Diseases ... Systemic lupus erythematosus ... connective tissue disease ... SLE), Sjogren's Syndrome ... ANA #patterns #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology ... #management
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Churg-Strauss syndrome ... systemic lupus erythematosus ... - Schnitzler syndrome ... - Sjögren syndrome ... Vessels #Diagnosis #Rheumatology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
Features: alveolitis, ear ... thromboembolic disease ... vasculitis • Hematologic ... myeloid cells NEJM ... Autoinflammatory #Somatic #rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
Congenital Diseases ... Wiskott-Aldrich syndrome ... and Autoimmune Diseases ... Systemic lupus erythematosus ... Differential #Diagnosis #Hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... Shrinking lung syndrome ... vein thrombosis Hematologic ... #Diagnosis #Rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation Syndrome ... Systemic lupus erythematosus ... systemic lupus erythematosus ... #Diagnosis #Management ... #Hematology #Rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Chain deposition disease ... antiphospholipid syndrome ... Systemic Lupus Erythematosus ... #differential #hematology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Systemic lupus erythematosus ... Systemic lupus erythematosus ... SLE), Sjogren's Syndrome ... Arthritis, Sjögren Syndrome ... ANA #patterns #rheumatology
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