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diagnosis hematology algorithm aplastic chronic cll erythematosus globulin lupus lymphocytic management mds monoclonal myelodysplastic pancytopenia paraproteinemias platelets protein proteingap rheumatology
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... telomeropathy Cancer ... : • Leukemia • ... #Diagnosis #Hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Chronic Myelogenous Leukemia ... • Hairy Cell Leukemia ... Myeloproliferative Disease ... blood count with differential ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... - infiltrates (anemia ... lymphoid organs When Cancer ... #Hematology #Oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
- Antithyroid medications ... • Hypocellular myelodysplastic ... syndrome (MDS) ... virus (EBV) • Leukemia ... #oncology #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
- Summary Cancer ... cells can indicate disease ... • Neutropenia, anemia ... diagnosis #workup #oncology ... #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Malignancy: Metastatic cancer ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... • Reaction to Medications
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
• Heavy Chain disease ... (-) hemolytic anemia ... Pseudohyponatremia • ↓anion gap ... #Monoclonal #Differential ... #Diagnosis #Oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... ovarian tumors, lung cancers ... : Lymphoma, Leukemia ... Thalassemia, Sickle cell anemia ... #ProteinGap #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... activation and/or medications ... Hodgkin lymphoma and leukemia ... • Lung cancer
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
Myelodysplastic ... syndromes current ... syndromes (MDS) ... acute myeloid leukemia ... tolerate anemia
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