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diagnosis hematology causes algorithm rheumatology associations connectivetissuediseases ctild effusion erythematosus extravascular hemolysis hemolytic ild intravascular lungdisease monoclonal pancytopenia paraproteinemias pericarditis
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... Wiskott-Aldrich syndrome ... • Leukemia • Lymphoma ... : • Systemic lupus ... #Diagnosis #Hematology
Connective tissue disease-associated interstitial lung diseases LIP: lymphoid interstitial pneumonia. NSIP: nonspecific interstitial pneumonia. OP: organizing pneumonia.
LIP: lymphoid ... PSS: Sjogren syndrome ... SLE : systemic lupus ... #Comparison #Table ... #Pulmonary #Rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... usually IgG) (e.g. lupus ... , CLL, lymphoma, ... Extravascular #Causes #differential ... #anemia
Causes of Pleural Effusion - Differential Diagnosis Algorithm Transudate - Hydrostatic • Congestive heart failure • Constrictive
Pleural Effusion - Differential ... Malignancy • Pulmonary ... Post-CABG • Medication ... • Asbestos • Uremia ... Diagnosis #Algorithm #Hepatology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Metastatic cancer, Lymphoma ... Vasculitides, IBD, Celiac disease ... Kawasaki, Nephrotic syndrome ... • Reaction to Medications
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Marginal Zone Lymphoma ... (-) hemolytic anemia ... to cold IgG • Lupus ... #Monoclonal #Differential ... #Diagnosis #Oncology
Causes of Acute Pericarditis: Infectious; Viral: Adenovirus Coxsackie virus A and B Echovirus Epstein-Barr virus Hepatitis Human immunodeficiency
Leukemia Lung Lymphoma ... - related Medication ... pericarditis) Uremia ... Systemic lupus ... #Pericarditis #Differential
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 SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Angioimmunoblastic T-cell lymphoma ... lymphopenia, low PLT • Anemia ... activation and/or medications ... cyclophosphamide) • Hodgkin lymphoma
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