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diagnosis causes algorithm hematology systemic dermatology generalized oncology thrombocytosis diseases erythematosus ild interstitial leukemia lung lupus mds myelodysplasia myelodysplastic naildisorders
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis - Differential ... Diagnosis Secondary ... malignancies • Anemia ... Myelodysplastic syndrome ... #secondary
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Pruritus - Generalized ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Myelodisplastic syndrome ... #primary #secondary
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Discoloration • Medications ... discoloration) • Chronic ... • Nephrotic syndrome ... #dermatology #Differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... hemolysis, deficiency anemia ... Kawasaki, Nephrotic syndrome ... • Reaction to Medications ... • Infections: Chronic
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Myelodisplastic syndrome ... #secondary #systemic
Interstitial Lung Diseases (ILD) Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis): • Hypersensitivity pneumonitis, Farmer's lung, Bird
pneumonitis • Medication-induced ... Methotrexate ILD Secondary ... Churg Strauss syndrome ... pneumonia: Acute, Chronic ... ILD #diagnosis #differential
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
sweats, bleeding • Pruritis ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... bone marrow and secondary
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Causes • Anemia ... Marrow Failure • Chronic ... blood count with differential ... #diagnosis #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Non-autoimmune rheumatologic ... lymphopenia, low PLT • Anemia ... with Lupus: • Chronic ... activation and/or medications
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