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causes hemolytic agglutinin algorithm atlas bloodcell disease erythematosus extravascular intravascular lupus microscopy morphology naildisorders nomenclature nonpalpable palpable platelet purpura rbc
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
usually IgM) (e.g. primary ... lymphoproliferative disorders ... infection) - Drugs ... Extravascular #Causes #differential ... #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Diagnosis Secondary ... malignancies • Anemia ... iron deficiency, hemolysis ... Post-splenectomy Primary ... #hematology #secondary
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Secondary Cold ... Secondary Cold ... Diagnosis: • hemolytic ... anemia • Cold ... #anemia #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/Quantity: • Primary ... anemia - Splenomegaly ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... Discoloration • Medications ... #Secondary #dermatology ... #Differential # ... Diagnosis #Algorithm
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Unstable hemoglobin disorders ... , Oxidative drugs ... cold hemoglobinuria ... RBC #Morphology #differential ... #diagnosis #hematology
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
into a 4-pass system ... Eosinophilic GI Disorders ... 3rd pass = Primary ... #Diagnosis #hematology ... #allergy
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
family history - Medications ... changes), high MCV anemia ... unclear, or if a primary ... hematologic disorder ... #Workup #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... the context of primary ... lymphopenia, low PLT • Anemia ... activation and/or medications ... #Rheumatology
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