6 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Lactic Acidosis (MALA ... ) Pathophysiology ... and acute kidney injury ... LacticAcidosis #Toxicity #Toxicology ... #Diagnosis #Management
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
caustic mucosal injury ... multi-organ failure (ARDS ... caustic bowel injury ... Poisoning #Toxicity #Toxicology ... #Diagnosis #Management
In ARDS, we know that the lungs are so diffusely injured that the remaining total area
In ARDS, we know ... are so diffusely injured ... , lung injury may ... #pathophysiology ... #diagnosis #management
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
monophasic Pathophysiology ... Presentation: Injury ... extensors of the arms ... Myelitis #diagnosis #management
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
cytotoxic lung injury ... organizing pneumonia, ARDS ... Pulmonary #diagnosis #management ... #Toxicology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
) Acute kidney injury ... hemolytic anemia (MAHA ... ) Pathophysiology ... endothelial cell injury ... of arteries Management