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diagnosis treatment hemophagocytic hlh lymphohistiocytosis differential disease hemeonc msk summary approach arthritis behcet capillary clarksons classification clinical dermatology dislocation erythematosus
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Macrophage Activation ... Liver function tests ... MAS #Macrophage #Activation ... #Management #Hematology ... #Rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Initial screening test ... block • Sjogren syndrome ... polymyositis overlap syndrome ... Summary #diagnosis #rheumatology ... #management
Susac Syndrome - Clinical Triad - Central nervous system dysfunction - Branch retinal artery occlusion -
Susac Syndrome - ... disease flares - 2-year ... David #Susac #Syndrome ... Triad #Diagnosis #Management ... #Rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Positive pathergy test ... is a skin prick test ... Giant retinal tears ... #diagnosis #management ... signs #symptoms #rheumatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
Diagnosis and Management ... complex → plt activation ... approach for post-test ... : Confirmatory test ... #Treatment #Hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... IFN-y) → Excessive activation ... Nicolas Taar ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
present both at rest ... improves quickly with rest ... trauma (e.g., meniscal ... tears) • Congenital ... Joint #Pain #MSK #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... excessive macrophage activation ... Lymphohistiocytosis #diagnosis #management ... #treatment #hematology
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO syndrome is ... blockers had the best ... #Rheumatology # ... diagnosis #management ... #Dermatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
VASCULITIS: • Behçet Syndrome ... • Cogan Syndrome ... well as inner ear ... retinopathy Lab Tests ... differential #diagnosis #rheumatology
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