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diagnosis differential causes algorithm hematology management endocrinology pathophysiology clinical anemia nephrology pharmacology diabetes iron neurology signs symptoms treatment physicalexam nutrition
Metformin in Diabetic Kidney Disease Immediate release: • Initial 500 mg or 850 mg once daily •
Metformin in Diabetic ... eGFR < 30: Stop metformin ... do not initiate metformin ... annually if on metformin ... of vitamin B12 deficiency
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
of Vitamin B12 Deficiency ... , H2 blockers, metformin ... #Vitamin #B12 #Deficiency
Anion Gap Metabolic Acidosis • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar • Alcoholic Ketoacidosis ± Hyperglycemia
Drugs ( Albuterol, Metformin ... - Thiamine Deficiency
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Transcobalamin II deficiency ... Drugs - Metformin ... #VitaminB12 #deficiency
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... titration • B12 deficiency ... EricsMedicalLectures/ #Metformin
Type B Lactic Acidosis Elevated lactic acid when no systemic hypoperfusion is apparent Causes: • Drugs (metformin, linezolid,
Causes: • Drugs (metformin ... metabolism • Thiamine deficiency
Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular
syndrome, Thiamine deficiency ... Lactate-based dialysate, Metformin
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
of Vitamin B12 Deficiency ... with vitamin B12 deficiency ... develop vitamin B12 deficiency ... • Deficient intrinsic ... Metformin blocks
Diabetes Combination Tablets - Estimated A1c Lowering Metformin + DPP4 • Janumet (metformin + sitagliptin) •
A1c Lowering Metformin ... DPP4 • Janumet (metformin ... • Jentadueto (metformin ... • Kombiglyze (metformin ... saxagliptin) Metformin
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
malignancy, or thiamine deficiency ... effect - Thiamine deficiency ... and Toxins: - Metformin
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