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Methadone.  Long half-life opioid originally developed in  1930s Germany.

#Pharmacology #Methadone #Methadose #Dolophine #Overview #Review
Methadone. ... #Pharmacology #Methadone ... #Methadose #Dolophine
Methadone - Pharmacology, Dosing and Interactions

Methadone is more of an Art than a Science, it’s a
Methadone - Pharmacology ... Interactions Methadone ... monitor the QTc #Methadone
Methadone Hospital Quick Start - Inpatient Initiation for Opioid Use Disorder and Withdrawal
Initial Dosing:
 - Patients
Methadone Hospital ... - Allergy to methadone ... give additional methadone ... #Methadone #Hospital
Quick Guide: Methadone Starts in the Hospital
Day 1: max daily dose 40 mg methadone
First dose
• Check
Quick Guide: Methadone ... daily dose 40 mg methadone ... Administer 10-30mg methadone ... daily dose 50 mg methadone ... Treatment (SHOUT) #Methadone
Methadone Drug-Drug Interactions
Meds that increase methadone metabolism/decrease methadone effect (INCREASED RISK FOR OPIOID WITHDRAWAL):
 • Phenytoin,
Methadone Drug-Drug ... that increase methadone ... metabolism/decrease methadone ... that decrease methadone ... Indinavir, Azoles #Methadone
Inpatient Management of Opioid Use Disorder: Methadone vs Buprenorphine - Comparison Table

Some patients may decline buprenorphine
Use Disorder: Methadone ... buprenorphine or methadone ... Treatment (SHOUT) #Methadone
Opioid Use Disorder Medications - Pharmacokinetics

Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
as morphine and methadone ... Methadone is a long-acting ... , morphine, or methadone ... Methadone exhibits ... #Pharmacology #Methadone
Methadone in Hospice & Palliative Care
Appropriate Candidates:
 - Moderate to severe pain
 - Pain refractory to
Methadone in Hospice ... risk factors for methadone ... projected time to methadone ... cindyPharMPH #Methadone
Acute Pain Control In Patients On Medication Assisted Treatment (MAT)
Methadone - µ-opioid receptor agonist:
1) Continue maintenance
Treatment (MAT) Methadone ... Buprenorphine #methadone
Torsades de Pointes 
•Precipitated by drugs that prolong the QT interval 
•Class IA antidysrhythmics (procainamide, quinidine)
Erythromycin •Methadone