7513 results
Methadone.  Long half-life opioid originally developed in  1930s Germany.

#Pharmacology #Methadone #Methadose #Dolophine #Overview #Review
Methadone. ... #Pharmacology #Methadone ... #Methadose #Dolophine
Methadone Hospital Quick Start - Inpatient Initiation for Opioid Use Disorder and Withdrawal
Initial Dosing:
 - Patients
Methadone Hospital ... - Allergy to methadone ... give additional methadone ... #Methadone #Hospital ... Inpatient #Initiation #management
CA-Bridge Buprenorphine Hospital Quick Start Algorithm - Management of acute opiate withdrawal 
 - Any prescriber
Start Algorithm - Management ... patient is stable on methadone ... or prefers methadone ... continuation of methadone ... dosing TID/QID #Management
Inpatient Management of Opioid Use Disorder: Methadone vs Buprenorphine - Comparison Table

Some patients may decline buprenorphine
Inpatient Management ... Use Disorder: Methadone ... buprenorphine or methadone ... Treatment (SHOUT) #Methadone ... Comparison #Pain #Management
Torsades de Pointes 
•Precipitated by drugs that prolong the QT interval 
•Class IA antidysrhythmics (procainamide, quinidine)
Erythromycin •Methadone ... TorsadesDePointes #Diagnosis
Methadone - Pharmacology, Dosing and Interactions

Methadone is more of an Art than a Science, it’s a
Methadone - Pharmacology ... Interactions Methadone ... monitor the QTc #Methadone ... Pain #Addiction #Management
Quick Guide: Methadone Starts in the Hospital
Day 1: max daily dose 40 mg methadone
First dose
• Check
Quick Guide: Methadone ... daily dose 40 mg methadone ... Administer 10-30mg methadone ... daily dose 50 mg methadone ... Algorithm #Treatment #Management
Buprenorphine-Naloxone and treatment of withdrawal symptoms

Prerequisites for starting Suboxone in the ED:

1. Patient has an opioid
acting), >72hr (methadone ... Withdrawal #Algorithm #Management
Opioid Use Disorder Medications - Pharmacokinetics

Buprenorphine is a partial mu-opioid receptor agonist with low intrinsic activity,
as morphine and methadone ... Methadone is a long-acting ... , morphine, or methadone ... Methadone exhibits ... #Pharmacology #Methadone
Torsades de Pointes
• "Twisting of the pointes" 
• QRS axis swings from positive to negative direction
Azithromycin Methadone ... TorsadesDePointes #Diagnosis